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Curology DayPrime Rx Acne Treatment + Blurring Primer
DayPrimeRx Wins Cosmopolitan 2025 Acne Award: Best Prescription Primer
A young woman holds a purple cylindrical bottle of Curology DayPrime Rx
A swatch of white cream Curology DayPrime Rx overlaid with text: - Personalized acne treatment for daytime use - Evens out texture and minimizes the look of pores - Visibly blurs imperfections - Helps treat acne with prescription active ingredients
Split image of a young woman before and after applying DayPrime Rx primer base and powder. In the before image, the woman's skin shows some acne, dark spots, and redness on her cheek. In the after image, her skin is smoother and more evenly toned.
A young woman swipes white cream Curology DayPrime Rx on her cheek. There's an overlaid image of a purple bottle of DayPrime Rx. Overlaid text says, "No filter needed" and "Minimize the look of pores."
Curology DayPrime Rx Acne Treatment + Blurring Primer
DayPrimeRx Wins Cosmopolitan 2025 Acne Award: Best Prescription Primer
A young woman holds a purple cylindrical bottle of Curology DayPrime Rx
A swatch of white cream Curology DayPrime Rx overlaid with text: - Personalized acne treatment for daytime use - Evens out texture and minimizes the look of pores - Visibly blurs imperfections - Helps treat acne with prescription active ingredients
Split image of a young woman before and after applying DayPrime Rx primer base and powder. In the before image, the woman's skin shows some acne, dark spots, and redness on her cheek. In the after image, her skin is smoother and more evenly toned.
A young woman swipes white cream Curology DayPrime Rx on her cheek. There's an overlaid image of a purple bottle of DayPrime Rx. Overlaid text says, "No filter needed" and "Minimize the look of pores."

DayPrimeᴿˣ

Acne Treatment + Blurring Primer

30-day supply • HSA|FSA-eligible

Introducing the first-ever prescription acne treatment and blurring primer in one.

Treat your acne with clinically proven active ingredients, while the primer base instantly improves the appearance of your skin at the same time. Formulated to visibly blur imperfections, minimize the look of pores, and even out texture. A soft-focus finish today, clearer-looking skin in the days ahead.

Important safety information

Made to treat:

Acne
Clogged pores
Skin texture
Oiliness
Dark spots
Rosacea
  • Award-winning. Fastest-selling. Cosmo-approved.
1st month*
just pay S&H$5.45
$29.95/mo

*Applies only to your first box. Trial lasts 30 days. Subject to medical consultation. New subscribers only. Restrictions apply.'

Let us find the right Rx treatment for you! Take the skin quiz

Dr. Whitney Tolpinrud, MD, FAAD, Curology's medical director
Dermatologist-tested icon
Dermatologist-tested
Non-comedogenic icon
Non-comedogenic
Paraben-free icon
Paraben-free
Fragrance-free icon
Fragrance-free
Sulfate-free icon
Sulfate-free
Vegan icon
Vegan
Cruelty-free icon
Cruelty-free

Treat and prime at the same time

  • Visibly blurs imperfections

  • Evens out texture

  • Minimizes the look of pores

  • Helps treat acne

A young man swipes a white cream dab of Curology DayPrime Rx on his cheek with his finger

Instant filter effect

No more choosing between treating and blurring. Finally, an acne treatment designed to wear under makeup. DayPrimeᴿˣ takes your average primer up a notch.

Results may vary.
A close-up of a young woman's face is split into two vertical panels. The left panel is labeled "Before" and shows her skin with visible acne and texture. The right panel is labeled "After" and shows her skin looking smoother and more even-toned.

Smooth skin now. Clearer skin over time.

Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Results may vary

Angelina

I've definitely noticed an improvement in my overall skin quality.

Selfie of real Curology patient Marina before using DayPrime Rx
Before
Selfie of real Curology patient Marina after using DayPrime Rx for 3 months. Her skin shows less acne and looks for evenly toned.
After 3 months
Selfie of real Curology patient Marina before using DayPrime Rx
Before
Selfie of real Curology patient Marina after using DayPrime Rx for 3 months. Her skin shows less acne and looks for evenly toned.
After 3 months
Results may vary

Marina

I really like DayPrimeᴿˣ—it makes my skin look smoother and helps my makeup go on better.

Selfie of real Curology patient Fanny before using DayPrime Rx
Before
Selfie of real Curology patient Fanny after using DayPrime Rx for 2 months. Her skin looks clearer.
After 2 months
Selfie of real Curology patient Fanny before using DayPrime Rx
Before
Selfie of real Curology patient Fanny after using DayPrime Rx for 2 months. Her skin looks clearer.
After 2 months
Results may vary

Fanny

[DayPrimeᴿˣ] is perfect if you’re looking for something practical for daily care.

Selfie of real Curology patient Alli before using DayPrime Rx
Before
Selfie of real Curology patient Alli after using DayPrime Rx for 2 months. Her skin shows faded dark spots and more evenness.
After 2 months
Selfie of real Curology patient Alli before using DayPrime Rx
Before
Selfie of real Curology patient Alli after using DayPrime Rx for 2 months. Her skin shows faded dark spots and more evenness.
After 2 months
Results may vary

Alli

I started using [Curology] to help with those stubborn dark spots that showed up during my pregnancy, and I cannot believe how much they’ve faded!

Selfie of real Curology patient Meki before using DayPrime Rx
Before
Selfie of real Curology patient Meki after using DayPrime Rx for 3 months. Her skin appears brighter, more even, and more matte.
After 3 months
Selfie of real Curology patient Meki before using DayPrime Rx
Before
Selfie of real Curology patient Meki after using DayPrime Rx for 3 months. Her skin appears brighter, more even, and more matte.
After 3 months
Results may vary

Meki

I feel that I use less makeup overall because my skin is brighter, smoother, and balanced with just the DayPrimeRx!

Selfie of real Curology patient Hayley before using DayPrime Rx
Before
Selfie of real Curology patient Hayley after using DayPrime Rx for 1 month. Her skin has less redness and fewer visible breakouts.
After 3 months
Selfie of real Curology patient Hayley before using DayPrime Rx
Before
Selfie of real Curology patient Hayley after using DayPrime Rx for 1 month. Her skin has less redness and fewer visible breakouts.
After 3 months
Results may vary

Hayley

A nice matte finish, reducing the loop of my combo/oily skin. I highly recommend!

Selfie of real Curology patient Bianca before using DayPrime Rx
Before
Selfie of real Curology patient Bianca after using DayPrime Rx for 3 months. Her skin is more evenly toned, clearer, and mattified.
After 3 months
Selfie of real Curology patient Bianca before using DayPrime Rx
Before
Selfie of real Curology patient Bianca after using DayPrime Rx for 3 months. Her skin is more evenly toned, clearer, and mattified.
After 3 months
Results may vary

Bianca

I love [DayPrimeᴿˣ] and definitely recommend it, especially for acne prone skin!

Selfie of real Curology patient Savannah before using DayPrime Rx
Before
Selfie of real Curology patient Savannah after using DayPrime Rx for 3 months. Her skin shows decreased redness and rosacea.
After 3 months
Selfie of real Curology patient Savannah before using DayPrime Rx
Before
Selfie of real Curology patient Savannah after using DayPrime Rx for 3 months. Her skin shows decreased redness and rosacea.
After 3 months
Results may vary

Savannah

After using [DayPrimeᴿˣ] for just a month, I’ve noticed a significant improvement in my redness.

Subject to medical consultation.

Proven ingredients, personalized formula

A provider analyzes your unique profile to prescribe 3 clinically proven active ingredients, personalized to target your skin goals.
AzAzelaic acid
azelaicAcid@2x

Gently exfoliates to help unclog pores, smooth texture, and brighten skin

    ClClindamycin phosphate
    clindamycin@2x

    Fights acne-contributing bacteria and soothes inflammation

      NiNiacinamide
      Niacinamide Drop

      Soothes inflammation, helps visibly fade dark spots, and fights free radicals

        ZiZinc pyrithione
        zincPyrithione@2x

        Soothes inflammation and acts against both bacteria and fungus that contribute to acne

          SaSalicylic acid
          Two clear liquid droplets of salicylic acid

          Goes deep into pores to clear away dead skin cells and excess oil

            DeDexpanthenol
            Dexpanthenol

            Attracts and holds moisture for softer, smoother skin

              Ingredients subject to medical consultation.

              The power duo for clearer skin

              Two custom Rx formulas work together to target your skin goals, day and night. Get your first month free* + $30 off each box after.

              *Trial lasts 30 days. Subject to medical consultation. New subscribers only.
              *Trial lasts 30 days. Subject to medical consultation. New subscribers only.

              FAQs

              What ingredients are in DayPrimeᴿˣ?

              A licensed dermatology provider selects 3 active ingredients at the right strength for your skin.

              Potential active ingredients include:

              • Azelaic acid: A multitasking exfoliant that helps unclog pores, smooth texture, and brighten skin

              • Clindamycin phosphate: An antibiotic that fights acne-contributing bacteria and soothes inflammation

              • Niacinamide: A form of vitamin B3 that soothes inflammation, helps visibly fade dark spots, and fights free radicals

              • Zinc pyrithione: An antimicrobial that helps keep bacteria and fungi in check while soothing inflammation

              • Salicylic acid: A chemical exfoliant that clears away dead skin cells, dirt, and excess oil

              • Dexpanthenol: A vitamin B5 derivative that attracts and holds moisture for softer, smoother skin

              Inactive ingredients: 1,2-hexanediol, butylene glycol, caprylyl glycol, ceramide NP, cetearyl olivate, dimethicone, glycerin, hydroxyacetophenone, oryza sativa (rice) starch, polyacrylate crosspolymer-6, polyhydroxystearic acid, polymethyl methacrylate, polymethylsilsesquioxane, polysorbate 20, PVP, sorbitan olivate, trisodium ethylenediamine disuccinate, water (aqua)

              Formulas containing dexpanthenol also contain propylene glycol.

              How do you use DayPrimeᴿˣ?

              Apply a thin layer of DayPrimeᴿˣ after your skincare routine, before sunscreen and makeup. Pair DayPrimeᴿˣ with a silicone-based foundation for best results.

              Gently pat (don’t rub!) into your skin and allow it to dry fully before your next layer. This helps lock in treatment benefits and prevents clumping or pilling, leaving your skin smooth and ready for whatever comes next.

              Since this is a prescription product, always follow your licensed dermatology provider’s instructions for how to best use it with your unique skin.

              What type of skin does DayPrimeᴿˣ work for?

              DayPrimeᴿˣ is personalized for your skin’s needs and can be designed to suit all skin types, specifically acne-prone skin.

              How is DayPrimeᴿˣ different from other acne treatments and primers?

              DayPrimeᴿˣ contains 3 clinically proven active ingredients to help treat acne and the primer base preps your skin for makeup with a blurring, filter-like effect. There’s nothing else like it!

              When will you see results?

              With consistent use, many patients using these types of ingredients notice a difference with their acne within 6-12 weeks—but everyone’s skin is different, so this timeline might vary for you. It’s also important to remember that this is a long-term journey! We’re not just going for progress, but also prevention.

              Can you use your HSA or FSA for Curology?

              You may be able to use your HSA or FSA pre-tax dollars for this Curology product, plus some of our other acne treatments and sunscreens. Check with your plan’s administrator to confirm eligibility. Restrictions apply.

              After your 30-day trial, you can update your payment method to your HSA or FSA card via your account dashboard. Or you can use a credit or debit card and submit a claim for reimbursement—just download your itemized receipt for your order from your account dashboard.

              Learn more

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