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Curology DayPrimeᴿˣ and Custom Formulaᴿˣ personalized acne treatments sit atop a glass shelf
Bundle Acne 02
A young man swipes a white dollop of DayPrime Rx acne treatment and blurring primer on his cheek. Overlaid text reads, "AM to PM Routine: Cleanse, Moisturize, Treat."
AM to PM: Routine graphic showing Curology DayPrime Rx for daytime treatment and Curology Custom Formula Rx for nighttime treatment
A hand holds up a purple bottle of Curology Day Prime Rx acne treatment and blurring primer. Overlaid text shows the clinically proven active ingredients that may be prescribed in your personalized Rx treatment, like azelaic acid and niacinamide
Split image with one side showing the instant blurring effect of Curology DayPrime Rx on a young woman's face before and immediately after applying the product. The other side shows a purple cylindrical bottle of DayPrime Rx with a white swatch behind it.
A brunette young woman holds bottles of Curology Custom Formula Rx and DayPrime Rx. Overlaid text provides clinical claims for the products. 90% of subjects agreed the DayPrime Rx base helped to blur the appearance of pores.
Curology DayPrimeᴿˣ and Custom Formulaᴿˣ personalized acne treatments sit atop a glass shelf
Bundle Acne 02
A young man swipes a white dollop of DayPrime Rx acne treatment and blurring primer on his cheek. Overlaid text reads, "AM to PM Routine: Cleanse, Moisturize, Treat."
AM to PM: Routine graphic showing Curology DayPrime Rx for daytime treatment and Curology Custom Formula Rx for nighttime treatment
A hand holds up a purple bottle of Curology Day Prime Rx acne treatment and blurring primer. Overlaid text shows the clinically proven active ingredients that may be prescribed in your personalized Rx treatment, like azelaic acid and niacinamide
Split image with one side showing the instant blurring effect of Curology DayPrime Rx on a young woman's face before and immediately after applying the product. The other side shows a purple cylindrical bottle of DayPrime Rx with a white swatch behind it.
A brunette young woman holds bottles of Curology Custom Formula Rx and DayPrime Rx. Overlaid text provides clinical claims for the products. 90% of subjects agreed the DayPrime Rx base helped to blur the appearance of pores.

AM to PM: Acne Routine

30-day supply • HSA|FSA-eligible

One simple routine that treats acne around the clock.

These two custom prescription formulas work together to target your skin goals for 24/7 treatment.

DayPrimeᴿˣ: Get soft-focus, smoother-looking skin and help treat acne with personalized, prescription active ingredients in this 2-in-1 daytime acne treatment and primer.

Custom Formulaᴿˣ: Help clear your skin with a personalized, prescription acne treatment made with 3 clinically proven ingredients selected to target your skin goals.

Made to treat:

Acne
Clogged pores
Skin texture
Oiliness
Dark spots
Rosacea
1st month*
just pay S&H$5.45
$59.90/mo

*Applies only to your first box. Trial lasts 30 days. Subject to medical consultation. New subscribers only. Restrictions apply.'

Let us find the right Rx treatment for you! Take the skin quiz

Dr. Whitney Tolpinrud, MD, FAAD, Curology's medical director
Dermatologist-tested icon
Dermatologist-tested
Non-comedogenic icon
Non-comedogenic
Paraben-free icon
Paraben-free
Fragrance-free icon
Fragrance-free
Sulfate-free icon
Sulfate-free
Vegan icon
Vegan
Cruelty-free icon
Cruelty-free

Results you can see and feel

Selfie of real Curology patient Marina before using DayPrime Rx
Before
Selfie of real Curology patient Marina after using DayPrime Rx for 3 months. Her skin shows less acne and looks for evenly toned.
After 3 months
Selfie of real Curology patient Marina before using DayPrime Rx
Before
Selfie of real Curology patient Marina after using DayPrime Rx for 3 months. Her skin shows less acne and looks for evenly toned.
After 3 months
Results may vary

Marina

I really like DayPrimeᴿˣ—it makes my skin look smoother and helps my makeup go on better.

Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Results may vary

Angelina

I've definitely noticed an improvement in my overall skin quality.

Alejandro - Before
Before
Alejandro - After
After 5 months
Alejandro - Before
Before
Alejandro - After
After 5 months
Results may vary

Alejandro

I love Curology. Their products have changed my life.

Jeanne - Before
Before
Jeanne - After
After 2.5 years
Jeanne - Before
Before
Jeanne - After
After 2.5 years
Results may vary

Jeanne

I honestly love Curology. It is the only sure thing for my skin.

Selfie of real Curology patient Fanny before using DayPrime Rx
Before
Selfie of real Curology patient Fanny after using DayPrime Rx for 2 months. Her skin looks clearer.
After 2 months
Selfie of real Curology patient Fanny before using DayPrime Rx
Before
Selfie of real Curology patient Fanny after using DayPrime Rx for 2 months. Her skin looks clearer.
After 2 months
Results may vary

Fanny

[DayPrimeᴿˣ] is perfect if you’re looking for something practical for daily care.

Aaliyah - Before
Before
Aaliyah - After
After 15 months
Aaliyah - Before
Before
Aaliyah - After
After 15 months
Results may vary

Aaliyah

I’m so glad I gave Curology a chance! I’m in love with my results!

Anjelica - Before
Before
Anjelica - After
After 2 years
Anjelica - Before
Before
Anjelica - After
After 2 years
Results may vary

Anjelica

There is such a huge difference from when I started. I am so happy with how my face looks now!

Stina - Before
Before
Stina - After
After 1 month
Stina - Before
Before
Stina - After
After 1 month
Results may vary

Stina

Within a month Curology has calmed my acne—I’m hooked!

Avalon - Before
Before
Avalon - After
After 1 year
Avalon - Before
Before
Avalon - After
After 1 year
Results may vary

Avalon

I hear constantly, ‘Your face looks so nice!’ I reply, ‘Thanks to Curology!’

Mista - Before
Before
Mista - After
After 3 months
Mista - Before
Before
Mista - After
After 3 months
Results may vary

Mista

It takes patience, but with Curology [it’s] worth it.

Lauren - Before
Before
Lauren - After
After 1 year
Lauren - Before
Before
Lauren - After
After 1 year
Results may vary

Lauren

Not only did Curology help with my acne, but my skin has been glowing too! I feel so much happier, confident, and myself!

Subject to medical consultation.

The power duo for clearer skin

Curology DayPrimeᴿˣ is your AM treatment for acne

First thing in the morning: DayPrimeᴿˣ

Prepare your skin for the day ahead with the first-ever prescription acne treatment and blurring primer in one. A soft-focus finish today, clearer-looking skin in the days ahead.

Curology Custom Formulaᴿˣ is your PM acne treatment

Last thing at night: Custom Formulaᴿˣ

Apply your personalized treatment after cleansing at night and let the custom combination of active ingredients go to work while you sleep.

Curology DayPrimeᴿˣ is your AM treatment for acne

First thing in the morning: DayPrimeᴿˣ

Prepare your skin for the day ahead with the first-ever prescription acne treatment and blurring primer in one. A soft-focus finish today, clearer-looking skin in the days ahead.

Curology Custom Formulaᴿˣ is your PM acne treatment

Last thing at night: Custom Formulaᴿˣ

Apply your personalized treatment after cleansing at night and let the custom combination of active ingredients go to work while you sleep.

Curology DayPrimeᴿˣ is your AM treatment for acne

First thing in the morning: DayPrimeᴿˣ

Prepare your skin for the day ahead with the first-ever prescription acne treatment and blurring primer in one. A soft-focus finish today, clearer-looking skin in the days ahead.

Curology Custom Formulaᴿˣ is your PM acne treatment

Last thing at night: Custom Formulaᴿˣ

Apply your personalized treatment after cleansing at night and let the custom combination of active ingredients go to work while you sleep.

Curology DayPrimeᴿˣ is your AM treatment for acne

First thing in the morning: DayPrimeᴿˣ

Prepare your skin for the day ahead with the first-ever prescription acne treatment and blurring primer in one. A soft-focus finish today, clearer-looking skin in the days ahead.

Curology Custom Formulaᴿˣ is your PM acne treatment

Last thing at night: Custom Formulaᴿˣ

Apply your personalized treatment after cleansing at night and let the custom combination of active ingredients go to work while you sleep.

Curology DayPrimeᴿˣ is your AM treatment for acne

First thing in the morning: DayPrimeᴿˣ

Prepare your skin for the day ahead with the first-ever prescription acne treatment and blurring primer in one. A soft-focus finish today, clearer-looking skin in the days ahead.

Treat and prime at the same time

Get smoother-looking skin and help treat acne at the same time.

  • Prescription active ingredients

  • Visibly blurs imperfections

  • Evens out texture

  • Minimizes the look of pores

Subject to medical consultation. Subscription required. Restrictions apply.
A brunette young woman holds a purple bottle of Curology DayPrimeᴿˣ

Custom-made for clearer skin

90.5%* of users report an improvement in acne at 3 just weeks using Custom Formulaᴿˣ

  • Targets acne, rosacea, dark spots, texture, and more

  • Reduces oiliness

  • Made using active ingredients selected for you

*Results may vary. In a clinical trial of 150 Curology patients after 3 weeks. Self-reported.
A hand holds up a bottle of Curology Custom Formulaᴿˣ personalized, prescription acne treatment. The label on the bottle shows that it's customized for acne, skin texture, and clogged pores.

Proven ingredients, personalized formulas

A provider analyzes your unique profile to prescribe 3 clinically proven active ingredients, personalized to target your skin goals.
TrTretinoin
tretinoin@2x

Helps clear acne and smooth out texture and fine lines

    AzAzelaic acid
    azelaicAcid@2x

    Gently exfoliates to help unclog pores, smooth texture, and brighten skin

      ClClindamycin phosphate
      clindamycin@2x

      Fights acne-contributing bacteria and soothes inflammation

        NiNiacinamide
        Niacinamide Drop

        Soothes inflammation, helps visibly fade dark spots, and fights free radicals

          ZiZinc pyrithione
          zincPyrithione@2x

          Soothes inflammation and acts against both bacteria and fungus that contribute to acne

            TraTranexamic acid
            tranexamicAcid@2x

            Helps lighten dark spots and reduce redness

              SaSalicylic acid
              Two clear liquid droplets of salicylic acid

              Goes deep into pores to clear away dead skin cells and excess oil

                DeDexpanthenol
                Dexpanthenol

                Attracts and holds moisture for softer, smoother skin

                  Ingredients subject to medical consultation.

                  Personalized to target your skin goals

                  A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

                  Formulated for you

                  Active ingredients hand-picked for your skin

                  A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

                  Science-backed for proven results

                  Dermatologist-tested and clinically studied for measurable results you can see and feel

                  A Curology licensed dermatology provider smiles in a white lab coat

                  Expert input at every step

                  Your provider is always available to answer questions and provide ongoing support

                  A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

                  Formulated for you

                  Active ingredients hand-picked for your skin

                  A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

                  Science-backed for proven results

                  Dermatologist-tested and clinically studied for measurable results you can see and feel

                  A Curology licensed dermatology provider smiles in a white lab coat

                  Expert input at every step

                  Your provider is always available to answer questions and provide ongoing support

                  A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

                  Formulated for you

                  Active ingredients hand-picked for your skin

                  A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

                  Science-backed for proven results

                  Dermatologist-tested and clinically studied for measurable results you can see and feel

                  A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

                  Formulated for you

                  Active ingredients hand-picked for your skin

                  A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

                  Science-backed for proven results

                  Dermatologist-tested and clinically studied for measurable results you can see and feel

                  A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

                  Formulated for you

                  Active ingredients hand-picked for your skin

                  Subject to medical consultation.

                  FAQs

                  What ingredients are in DayPrimeᴿˣ?

                  A licensed dermatology provider selects 3 active ingredients at the right strength for your skin.

                  Potential active ingredients include:

                  • Azelaic acid: A multitasking exfoliant that helps unclog pores, smooth texture, and brighten skin

                  • Clindamycin phosphate: An antibiotic that fights acne-contributing bacteria and soothes inflammation

                  • Niacinamide: A form of vitamin B3 that soothes inflammation, helps visibly fade dark spots, and fights free radicals

                  • Zinc pyrithione: An antimicrobial that helps keep bacteria and fungi in check while soothing inflammation

                  • Salicylic acid: A chemical exfoliant that clears away dead skin cells, dirt, and excess oil

                  • Dexpanthenol: A vitamin B5 derivative that attracts and holds moisture for softer, smoother skin

                  Inactive ingredients: 1,2-hexanediol, butylene glycol, caprylyl glycol, ceramide NP, cetearyl olivate, dimethicone, glycerin, hydroxyacetophenone, oryza sativa (rice) starch, polyacrylate crosspolymer-6, polyhydroxystearic acid, polymethyl methacrylate, polymethylsilsesquioxane, polysorbate 20, PVP, sorbitan olivate, trisodium ethylenediamine disuccinate, water (aqua)

                  Formulas containing dexpanthenol also contain propylene glycol.

                  What ingredients are in Custom Formulaᴿˣ?

                  A licensed dermatology provider selects 3 active ingredients at the right strength for your skin. 



                  Potential active ingredients include:

                  • Tretinoin: A prescription topical retinoid that helps clear acne and smooth out texture and can improve dark spots and fine lines

                  • Spironolactone: A medication that helps stop the cycle of persistent hormonal acne by reducing the skin’s oil production

                  • Azelaic acid: A multitasking exfoliant that helps unclog pores, smooth texture, and brighten skin

                  • Niacinamide: A form of vitamin B3 that soothes inflammation, helps visibly fade dark spots, and fights free radicals

                  • Clindamycin phosphate: An antibiotic that fights acne-contributing bacteria and soothes inflammation

                  • Zinc pyrithione: An antimicrobial that helps keep bacteria and fungi in check while soothing inflammation

                  • Tranexamic acid: A brightening amino acid derivative that helps visibly lighten dark spots and reduce redness

                  • Metronidazole: An antibiotic that can help soothe inflammation, including redness and swelling

                  • Ivermectin: A topical antimicrobial that can help treat rosacea and reduce its symptoms, like redness, inflammation, and acne-like bumps

                  Inactive ingredients: Aloe Barbadensis Leaf Juice, C13-C14 Isoparaffin, Caprylic/Capric Triglyceride, Deionized Water, Laureth-7, Phenoxyethanol, Polyacrylamide, Tocopheryl Acetate, Triethylene Glycol All formulas containing tretinoin also contain the antioxidant butylated hydroxytoluene (BHT). Formulas containing both niacinamide and azelaic acid, as well as formulas with spironolactone, may also contain propylene glycol.

                  How do you use DayPrimeᴿˣ and Custom Formulaᴿˣ?

                  In the AM: Apply a thin layer of DayPrimeᴿˣ to clean, dry skin and allow it to dry fully before adding sunscreen or makeup. Your personalized prescription will go to work targeting your long-term goals while keeping your skin smooth and ready for whatever comes next.

                  In the PM: Apply a thin layer of Custom Formulaᴿˣ after cleansing and allow to dry fully before moisturizing. Your personalized prescription will go to work while you sleep.

                  Since these are prescription products, always follow your licensed dermatology provider’s instructions for how to best use them with your unique skin.

                  How are the formulas personalized?

                  Your Curology dermatology provider will prescribe your formulas containing 3 active ingredients based on your skin quiz, photos, and medical history. Your formulas will target your specific skin concerns and can evolve with you over time!

                  When will you see results?

                  With consistent use, many patients using these types of ingredients notice a difference with their acne within 6-12 weeks—but everyone’s skin is different, so this timeline might vary for you. It’s also important to remember that this is a long-term journey! We’re not just going for progress, but also prevention.

                  Can you use your HSA or FSA for Curology?

                  You may be able to use your HSA or FSA pre-tax dollars for this Curology product, plus some of our other acne treatments and sunscreens. Check with your plan’s administrator to confirm eligibility. Restrictions apply.

                  After your 30-day trial, you can update your payment method to your HSA or FSA card via your account dashboard. Or you can use a credit or debit card and submit a claim for reimbursement—just download your itemized receipt for your order from your account dashboard.

                  Learn more

                  Explore more products

                  Bundle and save on Curology DayPrimeᴿˣ and HydroTretᴿˣ. They're HSA/FSA eligible.

                  AM to PM: Anti-Aging Routine

                  Your personalized AM and PM Rx treatments

                  $89.80 ($119.80 value)

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