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Two young women hold purple bottles of new Curology DayPrime Rx acne treatment + blurring primer. It's personalized with 3 clinically proven active ingredients and prescribed by a licensed dermatology provider.
Two young women hold purple bottles of new Curology DayPrime Rx acne treatment + blurring primer. It's personalized with 3 clinically proven active ingredients and prescribed by a licensed dermatology provider.

Your new daytime acne treatment

Introducing DayPrimeᴿˣ Acne Treatment + Blurring Primer—with personalized Rx ingredients to help clear your skin all day long.

*Applies only to your first box. Trial lasts 30 days. Subject to medical consultation. New subscribers only. Restrictions apply. Trial sizes not shown.

Treat and prime at the same time

Blur now, treat long term. The only Rx primer that fights acne all day long while locking your makeup in place.

  • Helps treat acne, dark spots, and texture

  • Visibly blurs imperfections

  • Evens out texture

  • Minimizes the look of pores

  • Designed to wear under makeup

Subject to medical consultation.
A close-up of a young woman's face is split into two vertical panels. The left panel is labeled "Before" and shows her skin with visible acne and texture. The right panel is labeled "After" and shows her skin looking smoother and more even-toned.

Smooth skin now. Clear skin over time.

Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Selfie of real Curology patient Angelina before using DayPrime Rx
Before
Selfie of real Curology patient Angelina after using DayPrime Rx for 1 month. Her skin appears clearer and smoother with less acne breakouts.
After 1 month
Results may vary

Angelina

I've definitely noticed an improvement in my overall skin quality.

Selfie of real Curology patient Hayley before using DayPrime Rx
Before
Selfie of real Curology patient Hayley after using DayPrime Rx for 1 month. Her skin has less redness and fewer visible breakouts.
After 3 months
Selfie of real Curology patient Hayley before using DayPrime Rx
Before
Selfie of real Curology patient Hayley after using DayPrime Rx for 1 month. Her skin has less redness and fewer visible breakouts.
After 3 months
Results may vary

Hayley

A nice matte finish, reducing the loop of my combo/oily skin. I highly recommend!

Selfie of real Curology patient Meki before using DayPrime Rx
Before
Selfie of real Curology patient Meki after using DayPrime Rx for 3 months. Her skin appears brighter, more even, and more matte.
After 3 months
Selfie of real Curology patient Meki before using DayPrime Rx
Before
Selfie of real Curology patient Meki after using DayPrime Rx for 3 months. Her skin appears brighter, more even, and more matte.
After 3 months
Results may vary

Meki

I feel that I use less makeup overall because my skin is brighter, smoother, and balanced with just the DayPrimeRx!

Selfie of real Curology patient Alli before using DayPrime Rx
Before
Selfie of real Curology patient Alli after using DayPrime Rx for 2 months. Her skin shows faded dark spots and more evenness.
After 2 months
Selfie of real Curology patient Alli before using DayPrime Rx
Before
Selfie of real Curology patient Alli after using DayPrime Rx for 2 months. Her skin shows faded dark spots and more evenness.
After 2 months
Results may vary

Alli

I started using [Curology] to help with those stubborn dark spots that showed up during my pregnancy, and I cannot believe how much they’ve faded!

Selfie of real Curology patient Savannah before using DayPrime Rx
Before
Selfie of real Curology patient Savannah after using DayPrime Rx for 3 months. Her skin shows decreased redness and rosacea.
After 3 months
Selfie of real Curology patient Savannah before using DayPrime Rx
Before
Selfie of real Curology patient Savannah after using DayPrime Rx for 3 months. Her skin shows decreased redness and rosacea.
After 3 months
Results may vary

Savannah

After using [DayPrimeᴿˣ] for just a month, I’ve noticed a significant improvement in my redness.

Subject to medical consultation.
A young woman holds a purple cylindrical bottle of Curology DayPrime Rx Acne Treatment + Blurring Primer. DayPrimeRx won the 2025 Cosmopolitan Acne Award for best prescription primer.
DayPrimeᴿˣ Wins Cosmopolitan 2025 Acne Award
“After taking an online quiz, you get sent a primer with a cocktail of Rx-strength ingredients for your exact skin concerns. Mine combines azelaic acid, niacinamide, and dexpanthenol to actively treat acne and soothe my skin while I prep for makeup.” —JH, Cosmopolitan Beauty Editor

Proven ingredients, personalized formula

A provider analyzes your unique profile to prescribe 3 clinically proven active ingredients, personalized to target your skin goals.
AzAzelaic acid
azelaicAcid@2x

Gently exfoliates to help unclog pores, smooth texture, and brighten skin

    ClClindamycin phosphate
    clindamycin@2x

    Fights acne-contributing bacteria and soothes inflammation

      NiNiacinamide
      Niacinamide Drop

      Soothes inflammation, helps visibly fade dark spots, and fights free radicals

        ZiZinc pyrithione
        zincPyrithione@2x

        Soothes inflammation and acts against both bacteria and fungus that contribute to acne

          SaSalicylic acid
          Two clear liquid droplets of salicylic acid

          Goes deep into pores to clear away dead skin cells and excess oil

            DeDexpanthenol
            Dexpanthenol

            Attracts and holds moisture for softer, smoother skin

              Ingredients subject to medical consultation.
              Dermatologist-tested icon
              Dermatologist-tested
              Non-comedogenic icon
              Non-comedogenic
              Paraben-free icon
              Paraben-free
              Fragrance-free icon
              Fragrance-free
              Sulfate-free icon
              Sulfate-free
              Vegan icon
              Vegan
              Cruelty-free icon
              Cruelty-free

              Personalized to target your skin goals

              A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

              Formulated for you

              Active ingredients hand-picked for your skin

              A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

              Science-backed for proven results

              Dermatologist-tested and clinically studied for measurable results you can see and feel

              A Curology licensed dermatology provider smiles in a white lab coat

              Expert input at every step

              Your provider is always available to answer questions and provide ongoing support

              A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

              Formulated for you

              Active ingredients hand-picked for your skin

              A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

              Science-backed for proven results

              Dermatologist-tested and clinically studied for measurable results you can see and feel

              A Curology licensed dermatology provider smiles in a white lab coat

              Expert input at every step

              Your provider is always available to answer questions and provide ongoing support

              A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

              Formulated for you

              Active ingredients hand-picked for your skin

              A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

              Science-backed for proven results

              Dermatologist-tested and clinically studied for measurable results you can see and feel

              A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

              Formulated for you

              Active ingredients hand-picked for your skin

              A hand holds up a purple cylindrical bottle of Curology DayPrime Rx acne treatment + blurring primer. Your formula is personalized to target your skin goals with clinically proven active ingredients prescribed by a licensed dermatology provider.

              Science-backed for proven results

              Dermatologist-tested and clinically studied for measurable results you can see and feel

              A redheaded woman swipes a dollop of white skincare cream on her face. Curology DayPrime Rx acne treatment + blurring primer is personalized with clinically proven active ingredients like azelaic acid, zinc pyrithione, and salicylic acid.

              Formulated for you

              Active ingredients hand-picked for your skin

              Subject to medical consultation.

              FAQs

              What ingredients are in DayPrimeᴿˣ?

              A licensed dermatology provider selects 3 active ingredients at the right strength for your skin.

              Potential active ingredients include:

              • Azelaic acid: A multitasking exfoliant that helps unclog pores, smooth texture, and brighten skin

              • Clindamycin phosphate: An antibiotic that fights acne-contributing bacteria and soothes inflammation

              • Niacinamide: A form of vitamin B3 that soothes inflammation, helps visibly fade dark spots, and fights free radicals

              • Zinc pyrithione: An antimicrobial that helps keep bacteria and fungi in check while soothing inflammation

              • Salicylic acid: A chemical exfoliant that clears away dead skin cells, dirt, and excess oil

              • Dexpanthenol: A vitamin B5 derivative that attracts and holds moisture for softer, smoother skin

              Inactive ingredients: 1,2-hexanediol, butylene glycol, caprylyl glycol, ceramide NP, cetearyl olivate, dimethicone, glycerin, hydroxyacetophenone, oryza sativa (rice) starch, polyacrylate crosspolymer-6, polyhydroxystearic acid, polymethyl methacrylate, polymethylsilsesquioxane, polysorbate 20, PVP, sorbitan olivate, trisodium ethylenediamine disuccinate, water (aqua)

              Formulas containing dexpanthenol also contain propylene glycol.

              How do you use DayPrimeᴿˣ?

              Apply a thin layer of DayPrimeᴿˣ after your skincare routine, before sunscreen and makeup. Pair DayPrimeᴿˣ with a silicone-based foundation for best results.

              Gently pat (don’t rub!) into your skin and allow it to dry fully before your next layer. This helps lock in treatment benefits and prevents clumping or pilling, leaving your skin smooth and ready for whatever comes next.

              Since this is a prescription product, always follow your licensed dermatology provider’s instructions for how to best use it with your unique skin.

              What type of skin does DayPrimeᴿˣ work for?

              DayPrimeᴿˣ is personalized for your skin’s needs and can be designed to suit all skin types, specifically acne-prone skin.

              How is DayPrimeᴿˣ different from other acne treatments and primers?

              DayPrimeᴿˣ contains 3 clinically proven active ingredients to help treat acne and the primer base preps your skin for makeup with a blurring, filter-like effect. There’s nothing else like it!

              When will you see results?

              With consistent use, many patients using these types of ingredients notice a difference with their acne within 6-12 weeks—but everyone’s skin is different, so this timeline might vary for you. It’s also important to remember that this is a long-term journey! We’re not just going for progress, but also prevention.

              Can you use your HSA or FSA for Curology?

              You may be able to use your HSA or FSA pre-tax dollars for this Curology product, plus some of our other acne treatments and sunscreens. Check with your plan’s administrator to confirm eligibility. Restrictions apply.

              After your 30-day trial, you can update your payment method to your HSA or FSA card via your account dashboard. Or you can use a credit or debit card and submit a claim for reimbursement—just download your itemized receipt for your order from your account dashboard.

              Learn more

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